TP53 and neoplasm: The PI3K/Akt system is strongly associated with both pro-inflammatory and anti-inflammatory responses, and the Akt signaling pathway has the ability to regulate activities including inflammatory cytokines and macrophage phagocytosis.[30,31] An essential tumor suppressor gene called TP53 is involved in cell cycle arrest, apoptosis, senescence, and carcinogenesis.[32] MicroRNAs (miRNAs) are a part of the TP53 signaling pathway.