The prevenient detection techniques such as fluorescence in situ hybridization and immunohistochemistry are unable to identify novel ALK fusion partners or resolve complex structural rearrangements, but NGS can.[4,5] With the widespread application of NGS, >90 ALK fusion partners have been identified in NSCLC.[6] EML4-ALK is the most frequent fusion variant of ALK rearrangements. This evidence concerns the gene ALK and non-small cell lung carcinoma.