The PI3K/Akt signaling pathway is necessary for insulin stimulation of glucose transport,[30,31] the impaired PI3K/Akt signaling pathway has been implicated in the development of IR.[32] In turn, IR would exacerbate the PI3K/Akt signaling pathway, forming a vicious cycle.[33] Thus, the PI3K/Akt signaling pathway may act as a molecular link between PCOS and IR. This evidence concerns the gene INS and polycystic ovary syndrome.