The possibility of platelet production failure due to decreased expression of TPO from hepatocytes has been reported as one factor in the thrombocytopenia of cirrhosis.[19] This phenomenon is something that does not occur in acute hepatitis, fulminant hepatitis, and other conditions.[20] However, there are many reports that TPO is constant or slightly decreased in the blood of cirrhosis patients. This evidence concerns the gene TPO and Fulminant hepatitis.