CSPG4 and neoplasm: Using in vitro and in vivo models, the same team [32] showed that CSPG4 controlled the tumor progression (local growth, cell adhesion, and motility, and cell survival) by mediating the interaction of sarcoma cells with the host extracellular matrix, in particular with collagen 6 (Col VI) that accumulates in the peri- and intra-lesional stroma.