The motif of the transcription factor SOX9 was also significantly enriched in the IP-DLBCL group (P = 1e−26) (Fig. 4F); SOX9 is an effective inducer of the formation of stem-like phenotypes, drug resistance, proliferation and invasion and can promote DLBCL development [35, 36]. The gene discussed is SOX9; the disease is diffuse large B-cell lymphoma.