In contrast, interleukin 25 (IL-25) is a member of the IL-17 family that can promote and augment T-helper (Th) type 2 responses, and overexpression of IL-25 is involved in lymphoma progression [29]; the level of gene body 5hmC signals on IL-25 was increased in all DLBCL samples compared with healthy control samples (Fig. 3D). The gene discussed is IL25; the disease is diffuse large B-cell lymphoma.