The results showed that the motif of the transcriptional enhancer factor signal transducer and activator of transcription 5 (STAT5) was significantly enriched in the IP-DLBCL group (P = 1e−95) (Fig. 4F); STAT5 is a downstream oncogenic mediator of the JAK-STAT pathway, and the activation of STAT5 promotes tumor progression in various human cancers, especially B cell lymphomas and leukemias [33, 34]. This evidence concerns the gene SOAT1 and leukemia.