In addition, the differentially enriched 5hmC genes were also significantly enriched in the “positive regulation of JAK-STAT cascade,” “cell–cell adhesion via plasma-membrane adhesion molecules” and “humoral immune response” in DLBCL of multiple primary sites, indicating that DLBCLs at different primary sites have certain canonical pathways in common. The gene discussed is SOAT1; the disease is diffuse large B-cell lymphoma.