The differential 5hmC genes were also significantly enriched in the “positive regulation of JAK-STAT cascade” in DLBCLs at multiple primary sites, which provides new insights into the activation of the JAK/STAT signaling pathway and indicates that the JAK/STAT signaling pathway may be a potential target of relapsed and refractory DLBCL. The gene discussed is SOAT1; the disease is diffuse large B-cell lymphoma.