The genes which contain more than or equal to two significant SNPs include genes ABCG2, SLC2A9, SLC17A1, ZNF518B, SLC17A3, GCKR, PKD2, MEPE, PDZK1, HECTD4, CD160, DNAJC16, TRIM46, CCDC63, ALDH2, and CUX2. Concerning AH, a total of 57 SNPs located in 13 genes were significantly associated with hyperuricemia compared to normal subjects (Supplementary Table 3; Fig. 1B). This evidence concerns the gene HECTD4 and hyperuricemia.