The results revealed that the variants exhibited protective effects against developing gout, namely rs3733589 (SLC2A9), rs3775948 (SLC2A9), rs1014290 (SLC2A9), rs3109823 (ABCG2), rs2622604 (ABCG2), rs6532055 (ABCG2), rs72554040 (ABCG2), rs671 (ALDH2), rs78069066 (MAPKAPK5), and rs77768175 (HECTD4). This evidence concerns the gene ALDH2 and gout.