The results revealed that the variants exhibited protective effects against developing gout, namely rs3733589 (SLC2A9), rs3775948 (SLC2A9), rs1014290 (SLC2A9), rs3109823 (ABCG2), rs2622604 (ABCG2), rs6532055 (ABCG2), rs72554040 (ABCG2), rs671 (ALDH2), rs78069066 (MAPKAPK5), and rs77768175 (HECTD4). The gene discussed is HECTD4; the disease is gout.