As for the distinction from HC, plasma p-tau181 showed the highest accuracy in discriminating AD from the other disease groups (FTD+PSP+CBS+DLB: cutoff > 1.98 pg/ml, sensitivity 86.6%, specificity 80.0%, AUC 0.889), in particular from FTD (AUC 0.964) and PSP (AUC 0.916), while its diagnostic value was lower for CBS (AUC 0.854) and DLB (AUC 0.806). Here, CBS is linked to Alzheimer disease.