SYK and acute respiratory distress syndrome: Moreover, previous studies showed that the inhibition of Syk reduced airway inflammation and facilitated mouse survival in an LPS-ALI mouse model [45].The repeated challenge of the fungal pathogen Aspergillus fumigates or β-glucan (the main cell wall component of various fungi) could lead to serious lung injury and the inhibition of Syk ameliorated β-glucan-induced inflammation, Th17/Treg imbalance, and lung tissue damage in BALB/C mice [46].