By acting as HDAC inhibitors, SCFAs significantly decrease AID and Blimp1 expression in B cells, reduce serum levels of class-switched autoantibodies, and abolish lupus-like skin lesions and kidney pathology in both MRL/lpr and NZB/W F1 mice, suggesting that dietary fibers and related catabolites produced by intestinal microbiota may exert beneficial effects for ameliorating autoimmunity [70]. This evidence concerns the gene AICDA and systemic lupus erythematosus.