These signature loci include hypomethylated sites near interferon-induced genes such as IFI44 and IFITM1 and hypermethylated CpGs surrounding SOX12, ARFGAP3, CCDC81, and MEG3. The DNA methylation patterns in B cells from healthy controls and SLE patients show clear differences, suggesting that the identified differentially methylated loci could be used as SLE biomarkers [12]. This evidence concerns the gene CCDC81 and systemic lupus erythematosus.