These signature loci include hypomethylated sites near interferon-induced genes such as IFI44 and IFITM1 and hypermethylated CpGs surrounding SOX12, ARFGAP3, CCDC81, and MEG3. The DNA methylation patterns in B cells from healthy controls and SLE patients show clear differences, suggesting that the identified differentially methylated loci could be used as SLE biomarkers [12]. The gene discussed is ARFGAP3; the disease is systemic lupus erythematosus.