The cellular glycoprotein Galectin-3-binding protein (Gal-3BP, Uniprot ID—Q08380), also known as 90 K, Mac-2 BP is a multidomain, multi-functional secreted protein that has been originally identified and characterized by our group13 and others14 as a tumor associated antigen and is involved in neoplastic transformation and cancer progression15,16. This evidence concerns the gene LGALS3BP and cancer.