Notably, genes associated with the glycolysis/gluconeogenesis pathway including LDHA —whose overexpression in cancer is associated with proliferation and malignancy54–56— and several glycolytic genes (e.g. HK1, VDAC1, and VDAC2) were only upregulated in LB fHER2− tumours and derived CLs (Tables S8 and 9). This evidence concerns the gene HK1 and neoplasm.