LAG3 and neoplasm: As in cutaneous melanoma, the anti-MAA clonotypes were enriched in uveal melanoma in the exhausted CD8+ T cell cluster (P < 2.2e−16, one-sided Fisher’s exact test, Fig. 2g, h), a cluster that upregulated PDCD1, HAVCR2 (TIM3), and LAG3. Also, in a cluster-agnostic analysis, the anti-MAA clonotypes overexpressed cytotoxicity and exhaustion-related genes e.g., NKG7, CCL5, PRF1, and LAG3 (Fig. 2i and Supplementary Data 3), showing convergence across tumor types.