Importantly, the anti-MAA clonotypes were enriched in the TCF7+ T cell cluster with stem-like properties (P = 2.2e−16, one-sided Fisher’s exact test), whose abundance has been associated with a response to immune checkpoint inhibitor therapies31, and in a cycling, exhausted CD8+ T cell phenotype (P = 0.0001), associated with tumor reactivity in the original publication30 (Fig. 2b, c). Here, TCF7 is linked to neoplasm.