When accounting for both common and rare coding variants at the nearby familial hypercholesterolemia LDLR gene, SPC24-enhancer DHS was significantly associated with total cholesterol (p-value = 3.01 × 10−11) and with suggestive evidence for LDL-C (p-value = 1.57 × 10−06). The gene discussed is SPC24; the disease is familial hypercholesterolemia.