Also, Wnt2 and Wnt9b are conserved in their high expression in hepatic ECs in multiple species, suggesting that these two Wnts may be most physiological for use in hepatic regenerative medicine for regulating LZ and LR, just like Wnt7a, Wnt7b, and Wnt10a, have been shown to be relevant during cholestasis.41 The gene discussed is WNT10A; the disease is cholestasis.