Also, Wnt2 and Wnt9b are conserved in their high expression in hepatic ECs in multiple species, suggesting that these two Wnts may be most physiological for use in hepatic regenerative medicine for regulating LZ and LR, just like Wnt7a, Wnt7b, and Wnt10a, have been shown to be relevant during cholestasis.41 This evidence concerns the gene WNT7B and cholestasis.