TP53 and rosacea: Through integration analysis of network pharmacology, metabolomics before and after doxycycline treatment, and transcriptomic analysis of liver tissue from doxycycline-treated and vehicle control–treated rats, we emphasized the critical role of glutamic acid and aspartic acid in the pathogenesis of rosacea and determined doxycycline-targeting gene TP53 was involved in glutamate metabolism, while PSEN1 was involved in aspartic acid metabolism.