APOB and coronary artery disorder: Amongst the top associations for this PGS was apolipoprotein B (apo B) (Beta = 0.027, 95% CI = 0.020 to 0.033, p = 7.2 × 10–15), which acts as an index of the number of circulating atherogenic lipoprotein particles and has been postulated previously to be the predominating lipoprotein lipid trait indexing CHD risk (Ference et al., 2019; Sniderman et al., 2019; Richardson et al., 2020b, Richardson et al., 2021).