Thus, H3/H6 and their nanoderivatives could robustlycounteract the rise of the intracellular ROS levels known to causedamage to lipids, proteins, and DNA in neurological disorders.53 Importantly, this, to our knowledge, is thefirst demonstration that neuritogenic motifs of the S100A4 proteincan suppress ROS production, suggesting that the parent protein mayalso be able to modulate neuronal ROS levels. Here, S100A4 is linked to nervous system disorder.