Higher levels of TnI, interleukins (IL‐1, IL‐10), and ET‐1 are related with WRF in SCA subjects developing AKI, and IL‐6 and ET‐1 seem to have a major role in the interaction among “de novo cardiac and renal impairment.”52. The gene discussed is EDN1; the disease is autosomal dominant cerebellar ataxia.