NP have the capacity to be a relevant diagnostic and prognostic resource in a wide spectrum of CRS types45, 46: elevated not just in CRS types 1 and 2, but also in CRS‐4, where BNP is a relevant parameter for recognizing acute HF in subjects with CKD and expects to be able to forecast cardiovascular events. This evidence concerns the gene NPPB and congenital rubella syndrome.