AKT1 and alkaline phosphatase measurement: The study found that abdominal paracentesis drainage attenuates severe AP by enhancing cell apoptosis via the PI3K-Akt signaling pathway.32 Wortmannin, PI3K-Akt signaling pathway inhibitor, attenuates severe AP in rats.33,34 Besides, FoxO emerges as a key factor for maintaining a functional endocrine pancreas.