CD4 and pancreatitis: For example, inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice.59 Cathepsin B (Ctsb) aggravates AP by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.60 mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4+ T cell immune response in AP.61 More importantly, the three key lncRNAs may also combine with other miRNAs to regulate the expression of autophagy genes and participate in the occurrence and development of AP.