The FoxO/Bcl6/cyclin D2 pathway regulates cell cycle control in pancreatic beta-cells.35 And a constitutively active form of FoxO3 also induced autophagy, suggesting FoxO3 as a downstream target of the PI3K pathway for autophagy inhibition.36 Based on the above evidence, we believe that PI3K-Akt and FoxO signaling pathways may be the main pathways of the autophagy gene in AP. This evidence concerns the gene CCND2 and alkaline phosphatase measurement.