Its inhibition prevented streptozotocin-induced diabetes and attenuated caerulein-induced AP.56 The targeted inhibition of Pten expression in AP can induce acinar cell apoptosis and inhibit inflammatory response.57 Pten phosphorylation promotes its nuclear translocation and autophagy, but the role of Pten in acinar cell autophagy is not clear.58 In general, some studies have shown the potential function of the above key genes in AP. This evidence concerns the gene PTEN and diabetes mellitus.