UROS and Congenital erythropoietic porphyria: More than 50 pathogenic mutations in UROS have been identified explaining the various clinical presentations of CEP ranging from severe antenatal manifestations causing hydrops fetalis to adult-onset mild cutaneous lesions.2 Congenital erythropoietic porphyria is characterized by severe skin photosensitivity and skin fragility, causing blisters, erosions, secondary skin infections, and later changes such as atrophy and mutilating scars.