INS and obesity due to melanocortin 4 receptor deficiency: In our previous study in male mice (Tencerova et al., 2018) and in the current study, obesity‐associated enhanced insulin signaling in BMSCs created a state of cellular hypermetabolism with increased mitochondrial oxidative phosphorylation (OXPHOS), and levels of reactive oxygen species that can lead to DNA damage and cellular senescence (Tencerova et al., 2019).