In humans, gluten interactions with the Transglutaminase 2 (TG2) enzyme are thought to be involved in the immunopathogenesis of celiac disease via the formation of TG2-gluten complexes and TG2-catalyzed deamidation of gluten peptides (Klöck et al., 2012; Amundsen et al., 2022; Paolella et al., 2022). Here, TGM2 is linked to celiac disease.