[1] CFRD is a progressive condition that is associated with worse clinical outcomes, decreased pulmonary function, and higher mortality rates. [2] Despite this, the pathogenesis of CFRD remains incompletely understood and is likely multifactorial. Studies show numerous factors associated with progression to CFRD including age, CFTR genotype, alterations in the exocrine pancreas, inflammation, loss of β-cell mass and reduced insulin production [3], [4], [5]. The gene discussed is INS; the disease is cystic fibrosis-related diabetes.