KCNH6 and glucose metabolism disease: We used global Kcnh6 KO and KCNH6-overexpressing mice and found that KCNH6 reduced mitochondrial and intracellular ROS levels by reducing mitochondrial and intracellular calcium levels and ultimately protected against oxidative stress and glucose metabolism disorders mediated via the JNK and p38MAPK signaling pathways (Figure 7).