At the same time, research suggests that the change in glucose metabolism is an important pathogenic process of pulmonary fibrosis, and the effects were linked to the TGF-β secretion, ECM synthesis, collagen production, glucose transporter, inflammatory response, and immune response (Selvarajah et al., 2021; Yin et al., 2021; Gopu et al., 2020). This evidence concerns the gene TGFB1 and pulmonary fibrosis.