CDX2 and colorectal carcinoma: We demonstrated the presence of binding sites for transcription factors involved in intestinal homeostasis and SC/cancer SC biology that are also altered in CRC [30, 31, 32], such as TCF7L2 (Wnt pathway) [33], RBPJ (Notch pathway) [34], and CDX2 (intestinal epithelial cell identity) [35].