AKT1 and neoplasm: Because mTORC1 is frequently activated in hepatocellular carcinoma and oral squamous cell carcinoma owing to mutations in the RTK/PI3K/AKT pathway [39, 40], it may be that deregulated mTORC1 signaling in these cancers promotes miR-130b-3p expression and subsequent acceleration of angiogenesis and tumor progression.