Notably, interaction with CXCL13-silenced MM cells induced significantly weaker induction of CXCL13 and RANKL expression in macrophages, in comparison with the original RPMI8226-CXCR4-GFP cells, suggesting the contribution of MM-secreted CXCL13 in CXCL13 and RANKL expression regulation in MΦ (Fig. 6C). This evidence concerns the gene CXCR4 and Miyoshi myopathy.