The cumulative frequencies of CD51/RANK-double positive subset (defined as osteoclast precursors population), MERTK+ and CD163+ CD206+ M2 macrophage subsets were significantly increased in BM samples from MM patients (n = 20) in comparison with healthy donors (n = 6) (Fig. 7C, upper panel). The gene discussed is ITGAV; the disease is Miyoshi myopathy.