Significant differences were found between the pSS moderate/advanced-ILD group (ILA score 2 + 3) and the pSS no-/indeterminate-ILD group (ILA score 0 + 1) based on age, IgM, CRP, eotaxin, KL-6, TGFα and TNFα levels (p < 0.05, Table 2 and Fig. 1). The gene discussed is CD40LG; the disease is interstitial lung disease.