Previous studies have shown that prognostic factors associated with the occurrence of pSS–ILD include older age, male sex, disease duration, smoking, an increase in anti-nuclear antibodies or rheumatoid factor, the presence of anti-SSA/Ro52 antibodies [11], low levels of circulating C3, and increased C-reactive protein levels [12–14]. This evidence concerns the gene TRIM21 and peeling skin syndrome.