To examine the function of newborn neurons, we saw increased cell numbers of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPARs)+ on Tuj1+ cells (APP/PS1 + PBMT: 16.28%; APP/PS1: 13.53%; 3xTg-AD + PBMT: 44.70%; 3xTg-AD: 33.51%) and postsynaptic density protein 95 (PSD95) + on Tuj1+ cells (APP/PS1 + PBMT: 33.27%; APP/PS1: 22.87%; 3xTg-AD + PBMT: 44.34%; 3xTg-AD: 36.40%) after PBMT-treated lymph nodes of AD mice (Fig. 2G). Here, APP is linked to Alzheimer disease.