NFKB1 and Alzheimer disease: Similarly, the signal transduction and cell behavior changes of astrocytes in the pathological development of AD are also associated with neuroinflammation [64], for example, the proliferation of reactive astrocytes can lead to the activation of nuclear factor kappa-B (NF-κB) signals in astrocytes, which triggers the production of nitric oxide (NO), which has a harmful effects on neurons when it is excessive [65, 66].