APP and Alzheimer disease: The results of our study indicated that PBMT treatment of APP/PS1 and 3xTg-AD mice's lymph nodes decreased the reactive astrogliosis, and strengthened the phagocytosis of microglia on Aβ plaques, which suggesting that PBMT reduced the neuroinflammation cascade effect in the brain tissue to a certain extent, improved the chronic inflammation of the CNS and provided favorable conditions for AHN under AD pathology.