In the present study, we verified that PBMT treatment activated the JAK2/STAT4/STAT5 signaling pathway, which subsequently upregulated the expression of IFN-γ/IL-10 in non-parenchymal CD4+ T cells, resulting in improving the expression levels of TGFβ1/IGF-1/BDNF in the brain of AD to promote AHN and synaptic plasticity of newborn neurons. Here, STAT4 is linked to Alzheimer disease.