Thus, our results indicated that PBMT treatment of lymph nodes promoted the expression of IFN-γ/IL-10 in non-parenchymal CD4+ T cells by activating the JAK2/STAT4/STAT5 signaling pathway, and induced the improvement of brain microenvironmental conditions, thereby playing a beneficial role in neurogenesis in AD mouse models. Here, CD4 is linked to Alzheimer disease.