Both NfL and pTau were strongly related to age and renal function and, in addition, were markedly affected by indicators of heart failure severity in the respective final model: NT-proBNP, an indicator of cardiac wall stress and congestion remained associated with NfL levels, and LAVI, an estimate of chronic elevation of cardiac filling pressures, as well as creatinine kinase, a marker of ongoing cardiac damage, remained associated with pTau. Here, NEFL is linked to heart failure.