In contrast, significant decreases in the expression levels of PPARγ, PINK1, and p-Parkin (Ser65) and the ratio of LC3-II/LC3-I, as well as a significant increase in SQSTM1/p62 expression, were observed in APP/PS1 cells cotreated with LPD and GW9662 or the mitophagy inhibitor Mdivi-1 (P < 0.01, Fig. 5A, B). This evidence concerns the gene PRKN and disseminated peritoneal leiomyomatosis.