Among them, PIP4K2B, which participates in 1-phosphatidylinositol-4-phosphate 5-kinase activity and IP6 [70], the product of 1-phosphatidylinositol-4-phosphate 5-kinase, can facilitates assembly of the immature HIV-1 Gag lattice [71], shows highly correlation (Fig. 5f), suggesting potential role of the PERVs in facilitating virus infection. The gene discussed is PIP4K2A; the disease is viral infectious disease.