CAV1 and lung cancer: In A549 and H1299 lung cancer cells, EMP2 downregulation by SPC can specifically promote caveolin-1 expression, enhance the combination of caveolin-1 and phosphatase 2A (protein phosphatase2a, PP2A), and induce PP2A detachment from its binding protein alpha 4, and finally result in PP2A ubiquitination and degradation.