In U373, U87MG, and gm97 malignant glioma cells, the expression of integrin αVβ3 on the cell surface is also positively correlated with EMP2, upregulating its expression, increasing the expression of integrin αVβ3, and promoting the proliferation and invasion of cells through activation of the FAK/SRC downstream pathway [103]. Here, EMP2 is linked to malignant glioma.