Without alpha 4 binding, the catalytic subunit of PP2A rapidly declines, and the dephosphorylation of PP2A family substrates is impaired, which will promote JNK and ERK phosphorylation and induce K8 phosphorylation and recombination, indirectly affecting the adhesion of tumor cells, and promoting tumor deterioration [111]. The gene discussed is MAPK8; the disease is neoplasm.