CD8A and colorectal carcinoma: The distribution of tumor-infiltrating immune cells in the high and low expression groups of B7-H4 was significantly different in CRC, which was shown in Fig. 3B. Particularly, patients with high B7-H4 expression had higher CD8+ T cells, iDC, NK CD56bright cells, T helper cells, Tcm, and Th2 cells (P < 0.05).