In contrast, plasma levels of P-SEL, MMP-1, ICAM-1, VEGF-A and VEGF-D either do not change with ME/CFS or are depressed (VanElzakker et al. 2019; Roerink et al. 2017; Roerink et al. 2018). The gene discussed is ICAM1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.