Since then, Src has been found to modulate glycolysis via different mechanisms, including regulation of master glycolytic transcription factors (HIF-1ɑ [63, 64] and MYC [65]), insulin secretion [66, 67], modulation of glycolytic enzyme activity by phosphorylation (HK, PFKFB3, G6PD), and through well-known Src substrates lying at the heart of energy metabolism and cancer, such as the PI3K-AKT-mTOR axis [68–70] and EGFR [71]. Here, PFKFB3 is linked to cancer.