Indeed, although mutations in Src are a rare event, both overexpression and overactivation of Src have been observed in numerous cancer types, including those of the brain, mainly glioblastoma (GBM), as well as cancer of the liver, lung, colon, breast, bladder and pancreas, contributing to their malignancy grade (Fig. 2, reviewed in [41]). The gene discussed is SRC; the disease is glioblastoma.