SLC2A1 and breast carcinoma: Since then, Src activity has been shown to regulate GLUT expression through two transcription factors: in astrocytes (nervous system cells) and GBM cells (their ‘tumoral counterpart’), Src activity can modulate the levels of GLUT-1 and GLUT-3 through HIF-1α protein levels [55, 78]; in breast cancer cells, Src inhibition can decrease MYC expression resulting in decreased GLUT-1 mRNA and protein levels [79].