The association between rare HNF1A functional domain variants and type 2 diabetes was more pronounced in individuals with a higher PRS compared to those with a lower PRS among those of European ancestry (ORinteraction=1.60, pinteraction=0.037), but not other ancestries (pinteraction=0.32 for the African population, pinteraction=0.45 for the Hispanic-Latino population) (Fig. 4). This evidence concerns the gene HNF1A and type 2 diabetes mellitus.