This in turn had a positive effect on the expression of ACOT8 gene with the aim of regulating the levels of acyl-CoA, free fatty acids and CoASH in order to prepare the muscle cell to a state of higher nutritional deficiency, since the overexpression of ACOT8 gene is associated with lipid accumulation and possibly a more adipogenic phenotype59. The gene discussed is ACOT8; the disease is nutritional deficiency disease.