Comparing IgM-MGRS with amyloidosis and non-amyloidosis, it was revealed that non-amyloid patients were more common to have renal dysfunction, hypertension, hematuria, anemia and hypocomplementemia, which might contribute to the difference between IgM-MGRS and IgG/IgA-MGRS. This evidence concerns the gene CD40LG and Abnormal renal physiology.