Comparing IgM-MGRS with amyloidosis and non-amyloidosis, it was revealed that non-amyloid patients were more common to have renal dysfunction, hypertension, hematuria, anemia and hypocomplementemia, which might contribute to the difference between IgM-MGRS and IgG/IgA-MGRS. The gene discussed is CD40LG; the disease is amyloidosis.