Two recent studies have evaluated brain metabolites in TgF344-AD rats: Chaney et al.32 reported decreased NAA levels in the hippocampus and increased Tau in the thalamus of 18 months old TgF344-AD rats, together with assessment of neuroinflammation, the acetylcholine system, Aβ plaque deposition and tau protein aggregates; while33 also reported a decrease in hippocampal NAA starting at 10 months of age together with decreases of taurine and creatine and increases in choline. This evidence concerns the gene MAPT and Alzheimer disease.