In the cortex, Tau and tCho concentrations were significantly affected by genotype (Tau: pgroup, ctx = 0.0092; tCho: pgroup, ctx = 0.0105) and showed significantly different temporal trajectories in TgF344-AD and WT animals (Tau: pinter, ctx = 8.08·10−5; tCho: pinter, ctx = 0.0445). The gene discussed is MAPT; the disease is Alzheimer disease.