ATF6 and myopia: However, since axial elongation was observed in the eyes without minus lenses, whether the activity was inhibited by GSK or knocked down by the CRISPR/Cas9 system, myopia was suppressed only when both PERK and ATF6 inhibitors were applied, and both PERK and ATF6 were required to inhibit collagen degradation by tunicamycin in vitro experiments, it can be assumed that ATF6 and PERK act together to control axial elongation.