TP53 and ovarian carcinoma: For example, in ovarian cancer, we observed that normal cells with over-expression of suppressor genes (i.e., TP53 and BRCA2)42 and lower-expression of oncogenes (i.e., MYC and NME1)43 are mainly enriched in domains 4, 5, 8, and 9, and normal and cancer cells are separated at the UMAP space (Supplementary Fig. 10c–e).