Molecular characterization of ccRCC has led to the identification of commonly mutated genes, including PBRM1, SETD2, and BAP1. After VHL, PBRM1 is the most commonly mutated gene in ccRCC, which, depending on context, can act as a tumor suppressor or oncogene16. Here, SETD2 is linked to nonpapillary renal cell carcinoma.