Following the co-expression and network analyses, this signature was found to be enriched for genes involved in the regulation of the stroma component of the tumor (TDO2, STEAP1) as well as Treg cells (SLC16A1, PRKAB1) and myeloid cell (APOBEC3A, MERTK, SNX29) subsets (Table 1). This evidence concerns the gene TDO2 and neoplasm.