The four gene families related to other cancers tumorigenesis8–12, including the SOX family (8.4%, SOX2 and other paralogs), the NR4A family (6.3%, NR4A2 and NR4A3), the ANKRD family (7.4%), and the CEA family (3.2%, gene cluster at cytoband 19q13.2), were new HPV-integrated hotspots identified in the large cohort of SCCC (Fig. 1). The gene discussed is NR4A3; the disease is cancer.