Moreover, focal CNA amplification peaks harbored canonical cancer genes including the HPV-integrated hotspots within MYC family, SOX2, et al. In light of discrepancies with regards to small cell carcinomas originating from other epithelial tissues, it is important to note that SCCC is a special subtype of cervical cancer due to HPV18/16 integrations and genomic alterations. This evidence concerns the gene SOX2 and small cell carcinoma.