ACE2 and infection: Accumulating evidence suggests that invasion of SARS‐CoV‐2 in ACE2‐expressing airway epithelial cells is followed by infection of endothelial cells, leading to endotheliitis.[27, 28] Vascular leakage caused by damaged endothelial cells provides the virus with a putative gateway to the circulatory system and other ACE2‐expressing organs.[28] Therefore, blockade of the spread of the virus from the blood circulation to peripheral organs is likely to prevent multisystem organ failure.