CFH and age-related macular degeneration: In the AMD feature-level analysis, the GRS was strongly associated with classical drusen, on separating eyes with SDD from eyes with both SDD and classical drusen, the association with the GRS lost significance despite previous studies showing a significant association between SDD and the two major AMD risk loci independent of drusen presence (ARMS2 positively associated and CFH Y402H negatively associated).33 We also observed that GRS was not significantly associated with hyperpigmentation when this feature present in the absence of drusen.