In contrast to our previous studies using chemical inhibitors to block SPP expression in WT mice, tamoxifen treatment to deplete SPP, or conditional knockout mice lacking SPP in their peripheral sensory neurons [19,24,28], the current study focused on blocking SPP expression in eye to specifically evaluate the role of SPP in virus replication in the eye of infected mice and its possible role in eye disease. Here, HM13 is linked to eye disorder.