We found that both siRNA-mediated depletion and CRISPR-Cas9 KD of SCAI significantly compromised RF progression post-UV in U-2 OS cells (Fig 5A and 5B) as well as in 2 additional cancer cell lines: TOV-21G (ovarian cancer) and WM3248 (melanoma) (S2C–S2E Fig). This evidence concerns the gene SCAI and melanoma.